Acetonitrile

1. Identification

Product Identifiers

Product Name

Acetonitrile

Other Names

Methyl cyanide; Ethanenitrile.

Product Number(s)

10020, 10021, EMS10020, EMS10021

CAS Number

75-05-8

Recommended use of the chemical and restriction on use

Company Details

Emergency Contact Details

2. Hazards Identification

Classification of the substance or mixture

Label Elements

Signal Words

None

Hazard Statement(s)

• Highly flammable liquid and vapour.
• Harmful if swallowed.
• Harmful in contact with skin.
• Harmful if inhaled.
• Causes serious eye irritation.

Precautionary Statement(s)

• Keep away from heat/sparks/open flames/hot surfaces. No smoking.
• Keep container tightly closed.
• Ground/bond container and receiving equipment.
• Use explosion-proof electrical/ventilating/lighting equipment.
• Use only non-sparking tools.
• Take precautionary measures against static discharge.
• Avoid breathing dust/fume/gas/mist/vapours/spray.
• Wash thoroughly after handling.
• Do not eat, drink or smoke when using this product.
• Use only outdoors or in a well-ventilated area.
• Wear protective gloves/protective clothing/eye protection/face protection.

Primary route(s) of entry

Human Health

Inhalation

Remove victim to fresh air and keep at rest in a position comfortable for breathing.

Ingestion

Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.

Eyes

Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice/attention.

Skin

(or hair) Remove/take off immediately all contaminated clothing. Rinse skin with water/shower. Take off contaminated clothing and wash it before reuse.

Environment

3. Composition / Information on Ingredients

4. First Aid Measures

Ingestion

Call for a doctor immediately.

Inhalation

Supply fresh air. If required, provide artificial respiration. Keep patient warm. Consult doctor if symptoms persist. In case of unconsciousness place patient stably in side position for transportation.

Skin Contact

Generally the product does not irritate the skin.

Eye Contact

Rinse opened eye for several minutes under running water. If symptoms persist, consult a doctor.

Other Information

• Show this safety data sheet to the doctor in attendance.
• Symptoms of poisoning may even occur after several hours; therefore medical observation for at least 48 hours after the accident.

5. Firefighting Measures

Suitable extinguishing equipment

Fire

CO₂, powder or water spray. Fight larger fires with water spray or alcohol resistant foam.

HAZCHEM

No further relevant information available.

Special protective equipment and precautions for fire fighters

6. Accidental Release Measures

Personal precautions, protective equipment and emergency procedures

Wear protective equipment. Keep unprotected persons away.

Environmental precautions

• Dilute with plenty of water.
• Do not allow to enter sewers/surface or ground water.

Methods and materials for containment and clean up

• Absorb with liquid-binding material (sand, diatomite, acid binders, universal binders, sawdust).
• Dispose contaminated material as waste according to item 13.
• Ensure adequate ventilation.

7. Handling and Storage

Precautions for safe handling

• Ensure good ventilation/exhaustion at the workplace.
• Keep ignition sources away - Do not smoke.
• Protect against electrostatic charges.

Conditions for safe storage

• Store in a cool location.
• Keep container tightly sealed.
• Store in cool, dry conditions in well sealed receptacles.

8. Exposure Controls / Personal Protection

Exposure Standards

Engineering controls

• Keep away from foodstuffs, beverages and feed.
• Immediately remove all soiled and contaminated clothing.
• Wash hands before breaks and at the end of work.
• Avoid contact with the eyes.
• Avoid contact with the eyes and skin.

Personal protective equipment

Eye and face protection

Tightly sealed goggles.

Skin protection

Wear protective gloves. The glove material has to be impermeable and resistant to the product/the substance/the preparation. Selection of the glove material on consideration of the penetration times, rates of diffusion and the degradation. The exact break through time has to be found out by the manufacturer of the protective gloves and has to be observed.

Body protection

Not available.

Respiratory protection

In case of brief exposure or low pollution use respiratory filter device. In case of intensive or longer exposure use self-contained respiratory protective device.

9. Physical and Chemical Properties

General information

Appearance

Colourless liquid

Odour

Aromatic

pH

Not determined.

Vapour Pressure

97.3hPa

Density

0.78-0.79g/cm³

Boiling Point

81.6°C

Melting Point

-46--45°C

Solubility

Fully miscible.

Specific Gravity of Density

Not available.

Flash Point

13°C

Flammable (Explosive) Limits

• Lower 3 Vol%
• Upper 16 VOL%

Ignition Temperature

Not determined.

Formula

Not available.

10. Stability and Reactivity

Reactivity

No further relevant information available.

Chemical stability

No decomposition if used according to specifications.

Possibility of hazardous reactions

No dangerous reactions known.

Conditions to avoid

No further relevant information available.

Incompatible materials

No further relevant information available.

11. Toxicological Information

Acute effects

• Oral LD50 2730 mg/kg (rat)
• Dermal LD50 1250 mg/kg (rabbit)

Eye contact

Causes serious eye irritation.

Skin contact

Based on available data, the classification criteria are not met.

Ingestion

Not available.

Inhalation

Based on available data, the classification criteria are not met.

Toxicity and irritation

• Germ cell mutagenicity Based on available data, the classification criteria are not met.
• Carcinogenicity Based on available data, the classification criteria are not met.
• ^. Reproductive toxicity Based on available data, the classification criteria are not met.
• STOT-single exposure Based on available data, the classification criteria are not met.
• STOT-repeated exposure Based on available data, the classification criteria are not met.
• Aspiration hazard Based on available data, the classification criteria are not met.

12. Ecological Information

Ecotoxicity

No further relevant information available.

Persistence and degradability

No further relevant information available.

Bioaccumulative potential

No further relevant information available.

Other adverse effects

• Water hazard class 2: hazardous for water.
• Do not allow product to reach ground water, water course or sewage system.
• Danger to drinking water if even small quantities leak into the ground.

13. Disposal Considerations

General information

14. Transport Information

ADG label required

HAZCHEM

No further relevant information available.

UN Number

UN1648

Proper shipping name

• ADG 1648 ACETONITRILE
• IMDG ACETONITRILE, MARINE POLLUTANT
• IATA ACETONITRILE

Transport hazard class

• Class 3 Flammable liquids
• Label 3

Packing group

II

Environmental hazard

• Yes (DOT)
• Symbol (fish and tree)

Special precautions for users

• Warning: Flammable liquids
• Hazard identification number (Kemler code): 33
• EMS Number: F-E,S-
• Stowage Category: B
• Stowage Code: SW2 Clear of living quarters.

Additional information

• Limited quantities (LQ): 1L
• Excepted quantities (EQ): Code: E2
• Maximum net quantity per inner packaging: 3mL
• Maximum net quantity per outer packaging: 500ml

15. Regulatory Information

Poisons Schedule Number

Not available.

Other Information

A Chemical Safety Assessment has not been carried out.

16. Other Information

SDS preparation date

8 April 2026

Comments

• Abbreviations and acronyms:
• ADR: Accord relatif au transport international des marchandises dangereuses par route (European Agreement Concerning the International
• Carriage of Dangerous Goods by Road)
• IMDG: International Maritime Code for Dangerous Goods
• IATA: International Air Transport Association
• EINECS: European Inventory of Existing Commercial Chemical Substances
• CAS: Chemical Abstracts Service (division of the American Chemical Society)
• LC50: Lethal concentration, 50 percent
• LD50: Lethal dose, 50 percent
• PBT: Persistent, Bioaccumulative and Toxic
• vPvB: very Persistent and very Bioaccumulative
• Flammable liquids - Category 2: Flammable liquids - Category 2
• Acute toxicity - oral - Category 4: Acute toxicity - Category 4
• Eye damage/irritation - Category 2A: Serious eye damage/eye irritation - Category 2A

References

• EMS SDS ACETONITRILE. 15/01/2025 https://www.emsdiasum.com/docs/technical/msds/10020.pdf
• Sigma-Aldrich SDS Acetonitrile-d3 08/11/2025 https://www.sigmaaldrich.com/AU/en/sds/aldrich/151807-userType=undefined.